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Anti-Aging Benefits of an Oxaloacetate Supplement:

The population is aging, and experts estimate that by 2050, 17 percent of people worldwide will be 65 and older.  Aging is often accompanied by declining health, and it is the biggest risk factor for many serious disorders, including cancer, cardiovascular disease, and neurodegenerative diseases.  However, this decline does not have to be an inevitable fact of life, and longevity science aims to preserve our health and quality of life as we age.

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Supplement makers have taken notice, and the market offers a range of anti-aging products that promise to increase energy and reduce the risk of many common age-related diseases.  Perhaps the most promising of these is the oxaloacetate supplement, based on a naturally occurring compound known to have profound health benefits, including improved brain function, balanced blood sugar, and increased energy.  Read on to discover how oxaloacetate supplements work and where you can find the best one for you.

How an oxaloacetate supplement mimics calorie restriction

For decades, caloric restriction (CR) has been studied for its effects on longevity and disease risk.  While animal studies have shown that CR can increase lifespan from 50-300%, human studies have also shown promise.  A two-year human study where subjects reduced their caloric intake by 14% showed benefits such as reduced abdominal fat, increased immune function, improved insulin sensitivity, and healthier blood vessels and hearts.  Of course, the main drawback of CR is that the average person might find it very challenging to maintain.

But what if you could enjoy the benefits of CR without having to follow the diet?  An oxaloacetate supplement can act as a calorie restriction mimetic, meaning that it replicates the physiological effects of CR.  Oxaloacetate achieves this effect primarily by improving the body’s ratio of NAD+ to NADH.  NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that boosts metabolism, helps recycle damaged cells, supports mitochondrial function, and repairs DNA damaged through the aging process.  It’s essential for the function of organs like the brain, heart, liver, and skin.  

Oxaloacetate supplement benefit:

1. Balanced blood sugar

Oxaloacetate is found naturally in the human body as an energy metabolite.  It plays an important role in gluconeogenesis, the conversion of non-carbohydrate nutrients to glucose.  An oxaloacetate supplement can help with weight management as it facilitates the conversion of fats and ketones in your diet to energy that you can use.  It also helps prevent sugar and carbohydrate cravings by regulating blood sugar levels.  The right oxaloacetate supplement can help you have more energy and manage your weight.   

Oxaloacetate supplement benefit:

2. Better brain health

Oxaloacetate affects neurological function by regulating the ratio of GABA to glutamate in the brain.  Glutamate is an essential amino acid and neurotransmitter that, when in excess, can cause cell damage or even cell death.  Researchers have found that oxaloacetate supplementation can reduce glutamate levels in the brain through a process called ‘glutamate scavenging.’  Therefore, oxaloacetate can have a substantial neuroprotective effect.  GABA is a neurotransmitter known to reduce stress levels and promote calm.  When oxaloacetate increases GABA and reduces glutamate, this positively affects mood and may improve emotional PMS symptoms in women. 

Oxaloacetate supplement benefit:

3. Increased cellular energy

A quality oxaloacetate supplement can improve your energy levels through its impact on mitochondrial function.  Mitochondria are the so-called ‘powerhouses’ of the cell.  These essential organelles generate most of the cellular energy required to power the biochemical reactions that keep us alive and give us energy.  Oxaloacetate performs a key function in the Krebs cycle within mitochondria, which provides energy to cells.  This helpful molecule also plays a role in mitochondrial biogenesis, the formation of new mitochondria within cells.   

Choosing the right oxaloacetate supplement

While you can find oxaloacetate in some foods, like daikon radish, cucurbita (gourd), and tarragon, this molecule degrades rapidly and is not easily absorbed.  Under normal conditions, oxaloacetate degrades rapidly unless stored at temperatures below -30 degrees Celsius.  For years, this presented a serious challenge to scientists hoping to create a usable oxaloacetate supplement. 

Fortunately, an answer came in 2006, with the founding of Terra Biological.  Terra Biological is an innovative company that has patented a method to thermally stabilize oxaloacetate using vitamin C, and their oxaloacetate supplement product is available as benaGene.  This San Diego-based leader in oxaloacetate supplementation offers the highest quality products at a reasonable price.  For about $42 per month, you can enjoy all the anti-aging benefits of oxaloacetate, including increased energy, improved brain health, and a healthier metabolism.   

What else can you do to increase your longevity?

In essence, much of the aging process can be traced to declining gene function and cell metabolism.  Because the nutrients we consume form the basis of our biochemistry, food acts as medicine.  A diet rich in plants and low in meat that incorporates moderate alcohol consumption has been shown to have positive effects on longevity.  Similarly, the right supplements can fuel our bodies and help protect us against many common age-related diseases. 

Those of us who live the longest also lead active lives, demonstrate sound psychological resilience, and live with a sense of purpose.  Incorporating all of these practices into your life will certainly help you increase your lifespan and your health-span.  If you incorporate the elements of this time-tested formula into your life, you may be surprised how energetic you feel into your golden years.

Further reading:

National Library of Medicine: Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis 

The Harvard Gazette: Longevity and anti-aging research: ‘Prime time for an impact on the globe’

CNN Health: The ‘Benjamin Button’ effect: Scientists can reverse aging in mice. The goal is to do the same for humans

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

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